NIH Working on Ebola Vaccine

NIH Clinical Center

NIH Clinical Center PHOTO | NIH

Human testing of a second investigational Ebola vaccine candidate is underway at the National Institutes of Health’s Clinical Center in Bethesda, according to the NIH website.

Researchers at the National Institute of Allergy and Infectious Diseases are conducting the early phase trial to evaluate the vaccine, called VSV-ZEBOV, for safety and its ability to generate an immune system response in healthy adults who are given two intramuscular doses, called a prime-boost strategy. The Walter Reed Army Institute of Research  is simultaneously testing the vaccine candidate as a single dose at its Clinical Trials Center in Silver Spring, according to the NIH press release.

“The need for a vaccine to protect against Ebola infection is urgent,” said NIAID Director Anthony S. Fauci, M.D. “NIH welcomes the opportunity to collaborate with the U.S. Department of Defense to conduct human clinical tests of another promising — and hopefully, successful — Ebola vaccine candidate.”

Early human testing of another investigational Ebola vaccine co-developed by NIAID and GlaxoSmithKline began in early September. Initial data on safety and immunogenicity (the capacity to generate an immune response) from clinical trials of the NIAID/GSK Ebola vaccine are expected by the end of 2014.

The NIH Phase 1 clinical trial of the VSV-ZEBOV vaccine candidate will enroll 39 healthy adults aged 18 to 65 years. Participants will be randomly assigned to one of three groups with 13 participants each. In each group, 10 participants will receive the investigational VSV-ZEBOV vaccine; three will receive a placebo.

For more information about how you can volunteer to be part of the clinical trial click here.

 
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Sonya Burke

About Sonya Burke

Sonya Burke is the Multimedia Manager at Montgomery Community Media (MCM). You can email story ideas at sburke@mymcmedia.org or reach her on Twitter @SonyaNBurke.

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